Web Directory

» A TV Show on RNAi by PBS
   NOVA scienceNOW TV program describes RNAi as a major breakthrough in gene therapy with enormous medical promise. Provides basic overview of RNAi technology, current therapeutic approaches, and interview with the experts in the field. Includes 15-minutes T
   http://www.pbs.org/wgbh/nova/sciencenow/3210/02.html

» Article on RNAi by GNN
   Online article describing gene silencing mechanism and how RNAi can be used for HIV treatment.
   http://www.genomenewsnetwork.org/articles/06_02/hiv.shtml

» Article on RNAi by HOPES
   Online article describes basic mechanism of RNAi and how it can be applied for Huntington's disease treatment.
   http://www.stanford.edu/group/hopes/treatmts/pbuildup/h2.html

» Article on siRNA from Wikipedia
   Describes small interfering RNA (siRNA) function, structure, use in research, and potential application for therapy.
   http://en.wikipedia.org/wiki/Small_interfering_RNA

» Cambridge Healthtech Institute
   CHI organizes RNAi-related conferences throughout the US and Europe, including therapeutics, pharmaceutics, drug development, target discovery, and biodefense. Provides biotechnology news and conferences information.
   http://www.healthtech.com/

» CnidBase
   Provides tools for researchers interested in studying gene expression of these organisms. Includes keyword search of genes and homologs, and a literature scan.
   http://cnidbase.org

» DBTGR - Database of Tunicate Gene Regulation
   Gene expression database of tunicates. Provides the descriptions of 12 transcription factors and 140 promoters.
   http://dbtgr.hgc.jp

» Discovery on Target
   Annual RNAi meeting hosted by Cambridge Healthcare Institute in Boston, Massachusetts. Online meeting information is available: plenary sessions, exhibits, and poster presentations.
   http://www.discoveryontarget.com

» Drosophila RNAi Resource
   Informational RNAi resource on studying drosophila genes and their roles in development by Society for Developmental Biology.
   http://www.sdbonline.org/fly/aignfam/rnaistuf.htm

» Fourth Annual Meeting of the Oligonucleotide Therapeutics Society
   Yearly conference organized by New York Academy of Sciences. Includes information about conference registration, preliminary program, and abstract submission.
   http://www.nyas.org/Publications/EBriefings/Detail.aspx?cid=c92e4e0f-132e-4dc8-be0f-9a855689fa5e

» Gene Silencing Mechanism
   Animation of post transcriptional gene silencing or RNA Interference (RNAi) by Nature Reviews Genetics.
   http://www.nature.com/nrg/journal/v2/n2/animation/nrg0201_110a_swf_MEDIA1.html

» Genetic Diversity
   Provides educational modules covering such parts of biology as genetics, cell biology, and gene expression.
   http://genetics.nbii.gov

» Induction of an interferon response by RNAi vectors in mammalian cells
   Article from journal Nature Genetics about potential complications of use of RNAi vector-based technology for therapeutics.
   http://www.nature.com/ng/journal/v34/n3/full/ng1173.html

» Journal of RNAi and Gene Silencing
   Publishes peer-reviewed articles addressing the biology and application of RNA interference and gene silencing. Includes information about journal aims and scope, publication policies, and manuscript submission. Provides online access to journal articles.
   http://www.libpubmedia.co.uk/RNAiJ/RNAiJHome.htm

» MicroRNA in Cancer
   Review of microRNA role in cancer by Nature journal. Provides full-length research papers and reviews.
   http://www.nature.com/nature/journal/v435/n7043/edsumm/e050609-16.html

» NANOPOLIS
   Educational portal providing nanotechnology articles and multimedia courses in the multidisciplinary research areas.
   http://www.nanopolis.net

» Nature web focus: RNAi
   Online review of RNA Interference biological phenomena. Includes citations of recent research publications, RNAi animations, and science news articles.
   http://www.nature.com/nature/focus/rnai/index.html

» Navigating Journey of Genome to Medicine
   Review article on RNAi by New York Times. Provides an overview on RNA Interference discovery, current research efforts, and therapeutic potential.
   http://www.nytimes.com/2005/06/22/health/22iht-snturn.html

» Nuclear Receptor Signaling Atlas
   Informational portal for researchers interested in nuclear receptor signaling.
   http://www.nursa.org/

» Oligoengine
   Oligonucleotide design software for applications such as RNAi, DNA methylation, antisense, and genome arrays.
   http://www.oligoengine.com

» Oligonucleotide Therapeutic Society
   Society host conferences on academia and industry-based research and development of oligonucleotide therapeutics: RNAi, antisense, and others. Provides society overview, publication materials, meetings, and contact information.
   http://www.myots.org/

» Ordway Research Institute
   Not-for-profit corporation with a mission to translate basic science observations into therapeutics. Provides research services including quantitation of endogenous levels of microRNAs and mRNAs from experimental samples. Includes information on research
   http://www.ordwayresearch.org

» RNA Interference
   Interactive online resource from Howard Hughes Medical Institute. Presents RNAi mechanism and overview of key scientific findings.
   http://hhmi.org/biointeractive/rna/rnai/

» RNA Interference at Journal Nature
   Focus RNA Interference - online resource publishing recent advances in RNAi field, and novel applications in Nature Cell Biology and Nature Reviews.
   http://www.nature.com/focus/rnai/

» RNAi Database
   Provides access to results from RNAi interference studies in C. elegans. Includes images, movies, phenotypes, and graphical maps. Many of the entries in the database are for ovary-expressed or germline-enriched genes.
   http://nematoda.bio.nyu.edu

» RNAi Gateway
   Web resource from BioMed Central. Provides RNA Interference (RNAi) research highlights, journal links, news, and meeting information.
   http://www.biomedcentral.com/gateways/RNAi/

» RNAi Mechanism Animation by Journal Nature
   An animation from Nature Publishing Group on the mechanism of RNA Interference (RNAi).
   http://www.nature.com/focus/rnai/animations

» RNAi News
   Online resource for scientists, researchers, technologists, and executives engaged in RNA Interference, functional genomics, and drug discovery. Offers industry news, product reviews, and meetings information.
   http://www.genomeweb.com/newsletter/rnai-news/

» RNAi Resource at Ambion
   Online RNA Interference (RNAi) resource. Provide scientific and technical support, information on microRNA and small interfering RNA application in gene expression research.
   http://www.ambion.com/techlib/resources/RNAi/

» RNAi Resource at Macalester College
   Informational resource, including RNAi mechanism, overview of current studies, and related research protocols.
   http://www.macalester.edu/~montgomery/RNAi.html

» RNAi Therapeutics: How Likely, How Soon?
   Review article from PLoS Biology journal. Describes mechanism of RNA Interference, potential applications towards therapeutics, and current problems associated with delivery.
   http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0020028

» RNAi Transfection Resource
   Review of transfection techniques such as electroporation, denrimers and lipids that are used for transfection of DNA, RNA, and siRNA. Includes information on optimized cell type specific transfection systems.
   http://cell-transfection.blogspot.com/

» RNAi.net
   Online resource offering information RNA interference and related issues: news, interviews, articles, techniques.
   http://www.rnai.net

» RNAi@elegansNet
   Directory on gene silencing by RNA interference (RNAi) literature and resources.
   http://c.elegans.tripod.com/RNAi.htm

» Rosetta Genomics
   Israel-based microRNA genomics company, develops bioinformatic tools for miRNA gene detection approach.
   http://www.rosettagenomics.com/

» SI RNA - Small Interference RNA Resources
   Online resource from Ion Channel Media Group. Provides news, publication links, and citations of the recent literature relevant to RNA Interference research.
   http://www.si-rna.com

» Silencing Genomes
   Portal about genome-wide applications of RNAi by Cold Spring Harbor Laboratory.
   http://silencinggenomes.org/

» Small RNAs: Delivering the future
   Article by journal Nature about development of RNAi therapeutics.
   http://www.nature.com/nature/journal/v450/n7172/full/4501117a.html

» TargetScan
   Online software provided by MIT for prediction of microRNA targets. Provides research data and online software for microRNA target identification and analysis.
   http://targetscan.org/

» The MIT/ICBP siRNA Database
   Online resource for researchers looking for experimentally validated siRNAs and shRNAs against target genes, with a focus on genes thought to be involved in cancer.
   http://web.mit.edu/sirna/

» The RNAi Cure
   A NOVA ScienceNOW science program by PBS feature the possible applications for RNAi therapy. Provides animations of key biological processes and mechanism of RNA Interference.
   http://www.pbs.org/wgbh/nova/sciencenow/3210/02-cure.html

» The RNAi Web
   Online resource for RNA Interference (RNAi) technology. Offers overview of technology, references, and links on other RNAi-related web resources.
   http://www.rnaiweb.com/

» The RNAi vs. HIV
   Reviews the use of this therapy in fighting HIV. Includes mechanism, difficulties, terms, and featured experiments.
   http://myweb.dal.ca/tbaptist/rnai/

» The siRNA User Guide
   Online guide for performing RNAi experiments using synthetic siRNA molecules. By Tuschl Lab at Rockefeller University.
   http://www.rockefeller.edu/labheads/tuschl/sirna.html

» Transcriptional Gene Silencing
   Mechanisms of TGS by Kevin Morris laboratory. Includes description of HIV research performed using lentiviral vector gene therapy and RNAi mediated gene silencing.
   http://www.scripps.edu/mem/rheum/morris/tgs/

» Wikipedia Article on RNAi
   Online article describing the basics of RNA Interference (RNAi) mechanism.
   http://en.wikipedia.org/wiki/RNA_interference

» miRNAMap
   Collection of published miRNAs from the microRNA registry and predict putative miRNA precursors based on genome-wide mapping of conserved RNA secondary structures.
   http://mirnamap.mbc.nctu.edu.tw/

» microRNA
   Online review of application for potential therapy of cancer.
   http://www.microRNA.ws