Web Directory

» 3D Structure of Prion Protein
   Interactive tutorial including Chime images depicting the 3D crystal structures of the globular domains of sheep and human prion proteins in normal and dimer forms.
   http://www.bio.davidson.edu/Courses/Molbio/MolStudents/spring2005/Winter/WholeFrame_files/ATPcAMPbuttons.htm

» Deadly Conformations-Protein Misfolding in Prion Disease
   Research article on prions.
   http://www.sciencedigest.org/499.HTM

» Kuru Information Page
   Compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
   http://www.ninds.nih.gov/disorders/kuru/kuru.htm

» Molecular Evolution of Prions
   Article arguing that the different evolutionary pathways of bovids and humans since a common ancestor 70 million years ago means that there seems to be no compelling reason why humans should contract CJD from beef.
   http://www.mad-cow.org/~tom/prion_evol.html

» Prion Diseases Overview
   General article about the prion hypothesis, the different diseases, and their possible treatment.
   http://www.microbiologybytes.com/virology/Prions.html

» Prion Illustration
   Computer graphic showing the replication and spread of prions in cells.
   http://www.rkm.com.au/BSE

» Prion Propagation in Vitro: Are We There Yet?
   In-depth analysis of prion disease progression in cellular and animal models, including the conversion of cellular prion protein to its disease-associated isoforms, various in vitro conversion assays and limitations.
   http://www.medsci.org/v05p0347.htm

» Prions
   Research project by Leslie Strama on these membrane glycoprotein particles including their classification, structure, the diseases caused and the future outlook.
   http://bioweb.uwlax.edu/bio203/s2008/strama_lesl/

» Protein Misfolding in Prion Disease
   Includes review of the pathogenesis of prion diseases.
   http://www.cyber-dyne.com/~tom/misfolding_review.html

» The Prion Protein
   Article by Alia Hinz and Christopher Doremus.
   https://www.msu.edu/~hinzalia/

» The Prion Protein Knockout Mouse
   Paper by Andrew D Steele, Susan Lindquist and Adriano Aguzzi discussing the multitude of phenotypes described in PrP deficient mice, many of which manifest themselves only upon physiological challenge.
   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634447/

» Wikipedia: Transmissible Spongiform Encephalopathy
   Defines TSEs, touches on possible vaccines or cures, and lists its variants.
   http://en.wikipedia.org/wiki/Transmissible_spongiform_encephalopathy

» eMedicine - Kuru : Article by Paul A Janson, MD
   A fatal neurologic disease that is restricted to the highlands of New Guinea, where it has infected the Fore (pronounced for-ay), a tribe of remote highland natives.
   http://emedicine.medscape.com/article/220043-overview